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Psychiatric disorders in adolescents are an important social problem relevant to almost all healthcare professionals, because the lifetime prevalence of anxiety, behavior, mood, and substance use disorders among adolescents is relatively high, but medical professionals are not sufficiently trained about adolescent psychiatric disorders. Primary care providers correctly identify less than a fourth of youth with a depressive or anxiety disorder and many clinicians underestimate the importance of the problem of adolescent psychiatric illnesses and suicidal behavior. Neurobiological aspects based on brain functional changes, depression, violence and abuse, post-traumatic stress disorder, substance abuse, military veteran issues, public health, cultural and legal issues are addressed in this book with relevant information for health professionals, since the mental health of adolescents and young adults is essential for sustaining healthy and productive societies.