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This book is an exploration of the nature of HIV/AIDS related stigma in rural Ghana. Despite the significant progress made in the reduction of new HIV infections, HIV/AIDS related stigma still remains one of the main challenges faced by rural communities globally. This book seeks to describe attitudes within the rural community of Wa about the disease, describe existing de-stigmatization approaches used by relevant bodies in the community, and also examines in a preliminary manner, the effectiveness of these approaches in reducing HIV/AIDS related stigma. Knowledge is not synonymous with behaviour change and is insufficient to effectively reduce stigma hence there is the need for more funding to embrace a broader and more effective stigma reducing strategies. HIV/AIDS related stigma is severe in rural Ghana due to rural social interaction and the implications of rural economics; strengthening the rights of the infected and affected would consequently reduce the effects of HIV/AIDS related stigma. HIV/AIDS related stigma continue to hamper efforts to prevent new infections, treatment, care, and support programmes.