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Antibiotics resistance is one of the major problems in the combat against infectious diseases. This is a crucial problem in all parts of the world especially in Africa and Asian regions. So this book provides updated information about the status of antibiotic resistance bacteria isolated from clinical sources such as wound, stool,urine and other body fluids among out patients and in patients of a Sub Saharan country Ethiopia, Debre Markos Referral Hospital. It also reviews the relationship of socio-demographic factors of the patients with that of the infections.