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Biodegradable in Situ Microparticles for Sustained Protein Delivery
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13 716
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The objective of this work was to evaluate the §suitability of in situ forming biodegradable §microparticles for the controlled delivery of §proteins. Particular goals were: a) to evaluate the §flexibility of the release patterns of in situ §implant and in situ microparticle formulations using §hen egg white lysozyme as model protein; b) to §characterize, if and how the integrity of the model §protein is affected by formulation ingredients, the §manufacturing process, storage of the ISM and the §release from the formulations; c) to optimize §protein delivery from in situ forming implant and §microparticle systems, with regard to shape and §completeness of the release; d) to find / validate §reliable methods allowing to extract and thus to §characterize the model protein in biodegradable in §situ formulations.
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