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This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. Cajal's fundamental contributions to neuroscience continue to be important today and this account accurately details his ideas and data. It also provides readers with the opportunity to learn what he thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.