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With Cytogenomics, Editor Thomas Liehr and leading contributors in the field demonstrate that chromosomes are crucial to understanding the human genome, and that new high throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to molecular cytogenetics, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jumpstart their own projects, and more effectively gather and interpret chromosomal data. Methods discussed include molecular cytogenetics, molecular karyotyping, GPCR, next generation sequencing, optical mapping, karyo-mapping, CRISPR-cas9, chromothripsis, and molecular combing. The book’s second half examines recent applications of cytogenomic approaches, such as characterizing 3D chromosome-structure across different tissue types, topologically associated domains, and chromothripsis. Offers applied approaches empowering a new generation of cytogenetic research using advanced chromatography methods and state-of-the art sequencing technologyProvides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and diseaseFeatures chapter contributions from international leaders in the field