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This book is about the herbal drug uses against the synthetic chemical drug in the treatment of the cigarette-smoke induced injury. we discuss the effects of cigarette smoking on the liver, plays a vital role in the metabolism of most of the drugs. The liver may be damaged by asthma, diabetes, alcohol consumption and also from chronic obstructive disease. Smoking causes architectural changes and leads to the malfunctioning of the organ. Smoking increases oxidative stress, chronic inflammation in the tissues and also enhances the production of stress kinases, inflammatory cytokines and lipid peroxidation which ultimately injures the liver.