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This book constitutes the refereed proceedings of the First IMIA/IFIP Joint Symposium on E-Health, E-Health 2010, held as part of the 21st World Computer Congress, WCC 2010, in Brisbane, Australia, in September 2010. The 22 revised full papers presented together with 10 poster papers were carefully reviewed and selected from 44 submissions. The papers cover a broad range of topics in the new interdisciplinary field of healthcare computing and communications offering basic research, healthcare applications and practice.