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Extended Release Tablet of Glipizide
Angličtina
112 b
Až 30 dní na vrácení zboží
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Brožovaná
263
Kč
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Brožovaná
355
Kč
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Brožovaná
554
Kč
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Brožovaná
988
Kč
The present investigation was to formulate and evaluate extended release tablet of glipizide using natural gum for the treatment of type II diabetes. Extended release tablet was prepared by employing hydrophobic diluents (DCP) and hydrophilic diluents (starch). Experimental work done: Preformulation studies and drug excipient profile were carried out for glipizide and dammar gum. Different batches of glipizide extended release tablets were prepared by using dicalcium phosphate and starch as diluents by wet granulation technique and direct compression method. Seven batches were made by changing concentration of dammar gum and change diluents in formulation. A physicochemical properties of dammar gum were evaluated such as acid value, iodine value, melting point, molecular weight. Result and Discussion: Results of preformulation study were satisfactory as no interaction was observed between glipizide and dammar gum by FTIR and DSC. All the pre and post compression parameters were tested. In vitro drug release profiles were examined, and compared with marketed product. The drug release of D5 batch is extended upto 98.22% in 12hr, and it follows korsmeyer peppas model.
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Brožovaná
299
Kč
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Brožovaná
621
Kč
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Brožovaná
671
Kč
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Brožovaná
722
Kč
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