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Shaping and cleaning of the root canal is one the most vital phase of endodontic therapy. The goal is to obtain a continuous tapering funnel flowing with the shape of the original canal from the coronal aspect to the root apex. As Dr. Clifford J.Ruddle rightly said "If you own the Glide Path, you can consistently win the rotary game of enodontics". Glide path introduced as a secret path to radicular safety making it the path of modern endodontics is to prevent the risk of instrument fracture. The chapters highlights the Indications and importance of Glide Path in Endodontics, the Measures to be taken to predictably prepare the Glide Path, the Instruments and Armamentarium in preparation of the Glide path, Methods to prepare the Glide Path, Anatomy of the Apical third of the Root Canal system and the Problems Associated without Glide path preparation. Routine Glide Path establishment and enlargement with Glide Path Files can increase the lifespan of rotary instruments with reduced risk of Instruments fracture.