Kontakt
Jak nakupovat
Doručení
Nákupní rádce
HIV Interactions with Host Cell Proteins
Angličtina
427 b
Až 30 dní na vrácení zboží
Zákazníci také koupili
/
Brožovaná
491
Kč
/
Brožovaná
554
Kč
/
Brožovaná
485
Kč
The authors seek to understand the assembly process of human immunodeficiency virus (HIV) and to develop a vaccine that can effectively neutralize HIV. HIV assembly is a process directed by the viral Gag polyprotein. Gag is a myristoylated precursor protein that is translated in the cytoplasm and then traffics to the plasma membrane or to endosomal vesicles for assembly. The authors have recently described an interaction between Gag and the delta subunit of the AP-3 adaptor protein complex (1). The mechanism and structural basis for this interaction is now under intense study. Our hypothesis is that the AP-3 interaction is responsible for the trafficking of Gag to the multivesicular body (MVB) and that this event is part of a normal productive particle assembly pathway. The Vpu protein of HIV assists the virus assembly process through a poorly-defined mechanism. The authors have presented evidence that Vpu overcomes a host cell restriction to assembly (2). Vpu appears to act through interactions with the recycling pathways in the cell, rather than directly interacting with Gag (3). The nature of the host restriction to assembly that Vpu overcomes is a focus of our ongoing work.
Informace o knize
Angličtina
Darujte tuto knihu ještě dnes
Je to snadné
1 Přidejte knihu do košíku a zvolte doručit jako dárek 2 Obratem vám zašleme poukaz 3 Kniha dorazí na adresu obdarovanéhoMohlo by vás také zajímat
/
Brožovaná
1 350
Kč
/
Pevná
2 185
Kč
/
Brožovaná
4 707
Kč
/
Brožovaná
444
Kč
/
Brožovaná
160
Kč
Ahoj! Jsem Libroamiko, tvůj knižní rádce.
Jak ti můžu pomoct?