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This book constitutes the thoroughly refereed post-conference proceedings of 18th International Workshop on Power and Timing Modeling, Optimization and Simulation, PATMOS 2008, featuring Integrated Circuit and System Design, held in Lisbon, Portugal during September 10-12, 2008.§The 31 revised full papers and 10 revised poster papers presented together with 3 invited talks and 4 papers from a special session on reconfigurable architectures were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on low-leakage and subthreshold circuits, low-power methods and models, arithmetic and memories, variability and statistical timing, synchronization and interconnect, power supplies and switching noise, low-power circuits; reconfigurable architectures, circuits and methods, power and delay modeling, as well as power optimizations addressing reconfigurable architectures.