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The book considers the lot-sizing and scheduling problem for flexible flow line production facilities. Flexible flow lines are flow lines with parallel machines on some or all production stages. They can be found in a vast number of industries. A three-phased solution approach is presented that solves the integrated lot-sizing and scheduling problem in a hierarchical manner. The approach is able to handle several important features relevant in industrial practice, such as back-orders and setup carry-over. The developed solution procedures solve practically sized problems in a relatively short amount of time. One of the procedures is based on a novel mixed integer programming (MIP) model, which employs integer variables instead of binary variables. This makes it possible to find (near-)optimal solutions using standard algorithms such as CPLEX. Another procedure uses two nested Genetic Algorithms. An application of the framework in the semiconductor industry is given. TOC:Introduction.- Lack of Solution Procedures in the Literature.- An Integrative Solution Approach.- Phase I: Bottleneck Planning.- Phase II: Schedule Roll-Out.- Phase III: Product-to-Slot Assignment.- An Illustrative Example.- An Application in the Semiconductor Industry.- Summary and Conclusions.