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Malaria Immunopathology
Signaling and Cellular Mechanisms Involved in Hemozoin-inducible Proinflammatory Events
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Plasmodium is the causative agent of malaria, the §most deadly parasitic infection worldwide. §Pathogenesis of the disease involves an exacerbated §immunological response; however, the role of §parasite components remains largely unexplored. The §current study was designed to assess the §contribution of hemozoin (HZ), a metabolic product §of Plasmodium, to the inflammatory events §associated to malaria. HZ was found to induce §various macrophage functions (e.g. chemokine and §nitric oxide production) through specific signaling §pathways. Importantly, the proinflammatory activity §of HZ was demonstrated in vivo (e.g. leukocytosis,§chemokine and cytokine release) using a murine §model. These findings support the idea that HZ §participates in inflammatory mediator overproduction §during malaria and therefore, it could be a key §component in the development of the disease. HZ §might emerge as an attractive target to design new §therapeutic approaches against malaria to prevent §millions of deaths. This book should be especially §useful to graduate students and researchers §interested in understanding the molecular and §cellular basis of malaria pathogenesis.
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