Signal Transduction and the Coordination of B Lymphocyte Development and Function I

This volume provides a review of current research in the field of B cell development and differentiation with particular emphasis on signal transduction processes. The volume is divided into two parts that focus, respectively, on the basic biochemical pathways which regulate B cell biology and the role of signal transduction processes in regulating various aspects of B cell function, development and differentiation. The chapters incorporated in part I include discussions of receptor mediated biochemical events that occur at the membrane, the intermediate pathways that transduce activation signals through the cell and, finally, the molecular events which regulate gene transcription in the nucleus of the B cell. In summary, the volume as a whole is designed to provide readers with an overview of signal transduction in the B cell and the role which signaling processes play in regulation of specific physiological events. TOC:Signal Transduction via the B-cell Antigen Receptor: The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphates.- The B-Cell Antigen Receptor: Formation of Signaling Complexes and the Function of Adaptor Proteins.- Intermediary Signaling Effectors Coupling the B-Cell Receptor to the Nucleus.- Involvement of the Lymphocyte Cytoskeleton in Antigen-Receptor Signaling.- Pax-5/BSAP: Regulator of Specific Gene Expression and Differentiation in B Lymphocytes.- Receptor Modulators of B-Cell Receptor Signalling - CD19/ CD22.- Positive and Negative Signaling in B Lymphocytes.