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Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases
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This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of the signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations in the lung of acute respiratory influenza virus infection and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system including beginning treatments in multiple sclerosis. One chapter reveals other possibly involved lipid molecules and their use for better understanding lipid signaling and their potential in the modulation of immune responses. §
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