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Synthesis and Activity of 1,3-diazines derivatives
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1 823
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558
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531
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715
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651
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For the first time there were obtained the new derivatives of quinazolinon-4 and 4-oxopyrimidine with the use of streptocide, sodium sulphathiazole, sulfadimezine and dapsone as amine components.we synthesize more than 15 new compounds of 4-oxopyrimidine and quinazolinone-4 derivatives with high yields and we determine their elucidation of structures by UV,IR,Elemental analysis and NMR.We explain why dimethyl yields more than diethyl.We use program PASS for the prediction of activity and the results obtained confirmed by 85%.We examine different activities and study the toxicity of the more active compounds.For the first time it was established hypoglycemic and glucosuric activity for the synthesized 1,3-diazines.The novelty of the synthesized compounds is confirmed with four priorities . 2006106046, .2006106056, . 2006111540 and . 2006111542 on patents of the Russian Federation. The results of quantum - chemical calculations of targeted compounds properties and their pharmacological activity are fixed on the basis of targeted synthesis of the predicted structures, representing derivatives of 4-oxopyrimidine and quinazolinone-4.
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