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Subduction to collision evolution of the Tethys ocean is marked as distinct relation with the regional metamorphism, volcanism, hydrothermal alteration and metallogeny related to the western segment of the Eurasian active margin metallogenic belt. Regional metamorphism and formation of granite-metamorphic complexes are related to the first stage of subduction occurs before steepening of subducting slab. Further increasing of temperature and andesite melt fusion led to transition to island arc-calc-alkaline volcanism coincided with gold-copper-base metal mineralization. The steepening of subducting slab (rollback, break off, detachment and delamination) and the invasion of the mantle diapir in the lithosphere induced interarc and backarc rifting, shoshonite-trachyandesite and tholeiite-alkaline-basalt volcanism with copper-zinc-pyrite mineralization. The further steepening of the subducting slab provoked intensive spreading and minor ocean setting with mantle type volcanic activity manifested in ophiolite series formation and ultrabasic dunite-peridotite magmatic activity with serpentinization and copper-pyrite mineralization.