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Schizophrenia is often associated with inadequate response to pharmacological and nonpharmacological treatments and there is evidence that treatment refractoriness worsens over time. This situation has given rise to much debate regarding the most appropriate treatment approach in this recalcitrant population. In this book, leading experts from Europe and the Americas provide a timely appraisal of the treatment of the most severely ill patients with schizophrenia. The book is clinically focused, yet informed by the latest research findings on both the neurobiology and the treatment of schizophrenia. It is comprehensive in scope, covering current medications, various add-on approaches and a range of cognitive and psychosocial treatments. The contributors are renowned experts who have fused their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia.§